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STUDIES

Studies on Testosterone Replacement Therapy (TRT)
OptimX Testosterone Replacement Therapy (TRT) Doctor
Your health is not something to be played with.

Here's a bunch of peer-reviewed studies and articles from the top institutions explaining and demonstrating the efficacy of TRT in improving quality of life and treating various conditions.
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TRT and Quality of Life

The following studies and articles demonstrate the effects of TRT on factors used to measure quality of life such as depression, anxiety, cognitive function, mood, etc:

  • Testosterone replacement therapy improves mood in hypogonadal men--a clinical research center study (Link)

  • Testosterone and Depression (Link)

  • Increased frequency of anxiety, depression, quality of life and sexual life in young hypogonadotropic hypogonadal males and impacts of testosterone replacement therapy on these conditions (Link)

  • Testosterone Replacement Therapy for Anxiety (Link)

  • Long‐Term Testosterone Treatment in Elderly Men with Hypogonadism and Erectile Dysfunction Reduces Obesity Parameters and Improves Metabolic Syndrome and Health‐Related Quality of Life (Link)

  • Effect of Testosterone Replacement Therapy on Cognitive Performance and Depression in Men with Testosterone Deficiency Syndrome (Link)

  • Testosterone Replacement Therapy with Long‒Acting Testosterone Undecanoate Improves Sexual Function and Quality‒of‒Life Parameters vs. Placebo in a Population of Men with Type 2 Diabetes (Link)

  • Systematic Review of the Impact of Testosterone Replacement Therapy on Depression in Patients with Late-onset Testosterone Deficiency (Link)

  • Testosterone for the aging male; current evidence and recommended practice (Link)

  • An update on the role of testosterone replacement therapy in the management of hypogonadism (Link)

  • A long-term, prospective study of the physiologic and behavioral effects of hormone replacement in untreated hypogonadal men (Link)

  • Testosterone replacement therapy for hypogonadal men with SSRI-refractory depression (Link)

  • Testosterone replacement therapy improves mood in hypogonadal men--a clinical research center study (Link)

TRT and Erectile Dysfunction

The following studies and articles demonstrate the effects of TRT on erectile dysfunction:

  • Testosterone Therapy in Erectile Dysfunction and Hypogonadism (Link)

  • Testosterone and Erectile Dysfunction (Link)

  • Testosterone Therapy Improves Erectile Function and Libido in Hypogonadal Men (Link)

  • The role of testosterone in erectile dysfunction (Link)

  • TESTOSTERONE SUPPLEMENTATION FOR ERECTILE DYSFUNCTION: RESULTS OF A META-ANALYSIS (Link)

  • Testosterone therapy in erectile dysfunction (Link)

TRT and Penile length

The following studies and articles demonstrate the effect of TRT on penile length:

  • Penile growth in response to human chorionic gonadotropin (HCG) treatment in patients with idiopathic hypogonadotrophic hypogonadism (Link)

  • The Use of Human Chorionic Gonadotropin (HCG) for Penile Reconstruction in Bladder Exstrophy and Total Epispadias Patients (Link)

  • Pattern of penile growth after HCG treatment in sever hypospadias might provide a clue to intra-natal endocrinopathy and pathogenesis (Link)

Low testosterone and Early death

The following studies and articles demonstrate the correlation between low testosterone and increased rate of mortality:

  • Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes (Link)

  • Low Testosterone Is Associated with Decreased Function and Increased Mortality Risk: A Preliminary Study of Men in a Geriatric Rehabilitation Unit (Link)

  • Low Testosterone Concentrations in Men Contribute to the Gender Gap in Cardiovascular Morbidity and Mortality (Link)

  • Low Serum Testosterone and Mortality in Older Men (Link)

TRT and Diabetes

The following studies and articles demonstrate the relationship between TRT and diabetes:

  • Metabolic effects of testosterone replacement therapy on hypogonadal men with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials (Link)

  • The effect of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes (Link)

  • Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes (Link)

  • Metabolic Effects of Testosterone Replacement Therapy in Patients with Type 2 Diabetes Mellitus or Metabolic Syndrome: A Meta-Analysis (Link)

TRT and Prostate Cancer

The following studies and articles demonstrate the relationship between TRT and prostate cancer:

  • Testosterone Replacement Therapy and Prostate Cancer (Link)

  • A New Era of Testosterone and Prostate Cancer: From Physiology to Clinical Implications (Link)

  • Testosterone, testosterone therapy and prostate cancer (Link)

  • Shifting the Paradigm of Testosterone Replacement Therapy in Prostate Cancer (Link)

  • The role of androgen therapy in prostate cancer: from testosterone replacement therapy to bipolar androgen therapy (Link)

  • Testosterone Replacement Therapy and the Risk of Prostate Cancer in Men With Late-Onset Hypogonadism (Link)

  • Prostate cancer risk in testosterone-treated men (Link)

  • Testosterone Replacement Therapy and Risk of Favorable and Aggressive Prostate Cancer (Link)

  • Testosterone Therapy in Men With Untreated Prostate Cancer (Link)

  • Testosterone and Prostate Cancer: Revisiting Old Paradigms (Link)

  • Serum Testosterone Level, Testosterone Replacement Treatment, and Prostate Cancer (Link)

TRT and Fertility

The following studies and articles demonstrate the relationship between TRT and fertility:

  • Concomitant Intramuscular Human Chorionic Gonadotropin Preserves Spermatogenesis in Men Undergoing Testosterone Replacement Therapy (Link)

  • HCG with TRT for Fertility and Testicular Atrophy (Link)

  • The Use of hCG Therapy to Maintain Fertility in Men on TRT (Link)

Benefits and risks of trt

The following studies and articles are an overall evaluation of TRT:

  • The benefits and risks of testosterone replacement therapy: a review (Link)

  • Testosterone for the aging male; current evidence and recommended practice (Link)

The Controversial Lower Limit

The following study takes a look at the controversial normal lower limit of testosterone as accepted by most physicians worldwide:

"Controversy in defining the clinical syndrome continues due to the high prevalence of hypogonadal symptoms in the aging male population and the non-specific nature of these symptoms. Further controversy surrounds setting a lower limit of normal testosterone, the limitations of the commonly available total testosterone result in assessing some patients and the unavailability of reliable measures of bioavailable or free testosterone for general clinical use. As with any clinical intervention testosterone treatment should be judged on a balance of risk versus benefit." (Stanworth RD, Jones TH. Testosterone for the aging male; current evidence and recommended practice. Clin Interv Aging. 2008;3(1):25-44. doi:10.2147/cia.s190) (Link)

Declining Testosterone Levels and increase in Erectile dysfunction

The following studies and articles shed light on the rapidly declining testosterone levels in men across the world and negative effects of this:

  • Decline in seminal quality in Indian men over the last 37 years (Link)

  • Over 25% urban Indian men have low testosterone (Link)

  • Why modern men are losing their testosterone (Link)

  • Men's testosterone levels declined in last 20 years (Link)

  • Generational decline in testosterone levels observed (Link)

  • Trends of male factor infertility, an important cause of infertility: A review of literature (Link)

  • Urban Indian Men Suffer from Low Testosterone Due to Unhealthy Lifestyle (Link)

  • Reasons for worldwide decline in male fertility (Link)

  • Brink of a fertility crisis: Scientist says plummeting sperm counts caused by everyday products (Link)

  • Erectile Dysfunction in Men on the Rise: Is There a Link with Endocrine Disrupting Chemicals? (Link)

  • The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences (Link)

  • In a first, India's fertility rate falls below replacement level | What it means (Link)